Environmental pollution and kidney diseases

Exposure to environmental pollutants is a major cause of kidney injury and disease worldwide and a particular problem in the developing world. In a Review, the authors discuss the different environmental pollutants that affect the kidney, and our understanding of their pathogenic mechanisms in kidney injury and disease.

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The effects of environmental pollution are a major global health challenge, with environmental pollutants accounting for an estimated 2.6 million deaths worldwide and 22 percent of the global burden of disease. The kidney is particularly vulnerable to environmental pollutants. A considerable proportion of the cardiac output of blood is delivered to the kidneys, where the blood is filtered and environmental toxins can become concentrated. An emerging body of evidence indicates that environmental pollutants, including particulate matter, heavy metals, and industrial and agricultural chemicals, are important risk factors for kidney disease, especially in developing countries in which environmental pollution is prevalent. In this Review, “Environmental pollution and kidney diseases,” the authors describe the epidemiological evidence supporting an association between kidney disease and exposure to environmental pollutants, as well as the potential biological mechanisms underlying this association.

Source: http://rdcu.be/JBbb (Nature Reviews Nephrology)

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