Junk food has lasting effects on the immune system
Lifestyle-associated pathologies have reached epidemic proportions and urgent action is needed to protect the public from unhealthy diets. It is now clear that the Western diet has long-lasting effects on the immune system that promote chronic metabolic inflammatory diseases.
Chronic consumption of a Western diet along with sedentary behaviour causes chronic metabolic inflammation (termed metaflammation) and is ‘memorized’ by innate immune cells through long-lasting metabolic and epigenetic cellular reprogramming.
Lifestyle-associated pathologies have reached epidemic proportions and require a better understanding of the causes of metaflammation and ways to translate this to measures that protect the public from unhealthy diets. The authors of this Comment present evidence of how environmental and obesogenic factors are integrated by the immune system, and discuss strategies to place public health above the interests of the food industry and lobbyists, in order to tackle lifestyle-associated inflammation.
By: Anette Christ and Eicke Latz/Nature Reviews Immunology